α-Bungarotoxin
目录号: A13935
nAChR antagonist
α-突吼毒素是烟碱型乙酰胆碱受体（nAChRs）的竞争性拮抗剂。α-突吼毒素，一种选择性的α7受体阻断剂，以 IC50 为 1.6 nM 阻断 α7 电流，并且在高达 3 μM 的浓度下对 α3β4 电流没有影响。
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生物活性
| Discription | α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC50 of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM. |
|---|---|
| References | Zhang et al (1994) Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels. Neuron 12 167 PMID: 7507338 Lopez et al (1998) Unmasking the functions of the chromaffin cell α7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. Proc.Natl.Acad.Sci.USA 95 14184 |
产品信息
| 目录号 | A13935 |
|---|---|
| 分子式 | C338H529N97O105S11 |
| 分子量 | 7984.12 |
| CAS号 | 11032-79-4 |
| Sequence | Ile-Val-Cys-His-Thr-Thr-Ala-Thr-Ser-Pro-Ile-Ser-Ala-Val-Thr-Cys-Pro-Pro-Gly-Glu-Asn-Leu-Cys-Tyr-Arg-Lys-Met-Trp-Cys-Asp-Ala-Phe-Cys-Ser-Ser-Arg-Gly-Lys-Val-Val-Glu-Leu-Gly-Cys-Ala-Ala-Thr-Cys-Pro-Ser-Lys-Lys-Pro-Tyr-Glu-Glu-Val-Thr-Cys-Cys-Ser-Thr-Asp-Lys-Cys-Asn-Pro-His-Pro-Lys-Gln-Arg-Pro-Gly (Disulfide bridge: Cys3-Cys23;Cys16-Cys44;Cys29-Cys33;Cys48-Cys59;Cys60-Cys65) |
| Sequence shortening | IVCHTTATSPISAVTCPPGENLCYRKMWCDAFCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG (Disulfide bridge: Cys3-Cys23;Cys16-Cys44;Cys29-Cys33;Cys48-Cys59;Cys60-Cys65) |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 11032-79-4 | 11032-79-4 供应商 | 11032-79-4 花费 | 11032-79-4 生产商 | 订购 11032-79-4 | 11032-79-4 代理商