AM 114

Name: AM 114
SKU: A14922
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A14922

20S proteasome 抑制剂

AM 114，一种硼烷查尔酮衍生物，是一种强效的小分子蛋白酶体抑制剂，能够抑制20S蛋白酶的胰蛋白酶样活性，其50%抑制浓度（IC50）约为1 uM，导致泛素化的p53和其他细胞蛋白在整个细胞中显著积累，而不会显著干扰p53与小鼠双分钟2蛋白（mdm2）的相互作用。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥280.00	现货
25mg	¥630.00	现货
50mg	¥1,155.00	现货
100mg	¥1,960.00	现货
200mg	¥2,835.00	现货
*10mM 1mL in DMSO**	¥280.00	现货
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Data Sheet

SDS

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生物活性

Discription

AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A14922
分子式	C20H21B2NO5
分子量	377.01
CAS号	856849-35-9
SMILES	B(C1=CC=C(C=C1)C=C2CN(CC(=CC3=CC=C(C=C3)B(O)O)C2=O)C)(O)O
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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