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在CXCR4 125I-SDF抑制结合试验中，AMD-070 HCl是一种有效的选择性CXCR4拮抗剂，IC50值为13 nM，抑制T-4型HIV-1（NL4.3株）在MT-4细胞中的复制和PBMC。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.79 mL | 108.97 mL | 217.93 mL |
| 0.5 mM | 4.36 mL | 21.79 mL | 43.59 mL |
| 1 mM | 2.18 mL | 10.9 mL | 21.79 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.36 mL |
*The above data is based on the productmolecular weight 458.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14997 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 458.86 |
| Formula | C21H30Cl3N5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 880549-30-4 |
| Synonyms | AMD070 hydrochloride, AMD 070 hydrochloride |
| SMILES | C1CC(C2=C(C1)C=CC=N2)N(CCCCN)CC3=NC4=CC=CC=C4N3.Cl |
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