AMG-073 HCl (Cinacalcet HCl)

Name: AMG-073 HCl (Cinacalcet HCl)
SKU: A10219
Price: 210 CNY
Rating: 5 (288 reviews)

目录号: A10219

CaSR activator

AMG-073 HCl（辛钙片盐酸盐）代表了一种新的化合物类别，用于治疗甲状旁腺功能亢进症，称为钙效应增强剂，它通过增加甲状旁腺钙感受器（CaR）对细胞外钙的敏感性，来减少甲状旁腺激素（PTH）的合成和分泌。

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Grouped product items
规格	价格	库存
5mg	¥210.00	现货
10mg	¥245.00	现货
25mg	¥385.00	现货
50mg	¥525.00	现货
100mg	¥980.00	现货
200mg	¥1,330.00	现货
500mg	¥2,240.00	现货
*10mM 1mL in DMSO**	¥280.00	现货
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Data Sheet

SDS

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生物活性

Discription

AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium.

Targets

Target	Value

产品信息

目录号	A10219
分子式	C22H23ClF3N
分子量	393.9
CAS号	364782-34-3
SMILES	C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl
其他名称	Mimpara, Sensipar
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	67 mg/mL (170.1 mM)
	Water	Insoluble
	Ethanol	28 mg/mL (71.09 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.39 mL	126.94 mL	253.87 mL
0.5 mM	5.08 mL	25.39 mL	50.77 mL
1 mM	2.54 mL	12.69 mL	25.39 mL
5 mM	0.51 mL	2.54 mL	5.08 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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