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AMG-073 HCl（Cinacalcet HCl）是一种用于治疗甲状旁腺功能亢进的化合物，称为拟钙剂，通过增加甲状旁腺钙敏感受体（CaR）对细胞外钙的敏感性来减少甲状旁腺激素（PTH）的合成和分泌 。
靶点信息
| CaSR | ||||
| 2.8 μM |
| In vitro (25°C) | DMSO | 67 mg/mL (170.1 mM) | |
| Water | Insoluble | ||
| Ethanol | 28 mg/mL (71.09 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.39 mL | 126.94 mL | 253.87 mL |
| 0.5 mM | 5.08 mL | 25.39 mL | 50.77 mL |
| 1 mM | 2.54 mL | 12.69 mL | 25.39 mL |
| 5 mM | 0.51 mL | 2.54 mL | 5.08 mL |
*The above data is based on the productmolecular weight 393.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10219 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 393.9 |
| Formula | C22H23ClF3N |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 364782-34-3 |
| Synonyms | Mimpara, Sensipar |
| SMILES | C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl |
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