产品详情

生物活性

AMG 208是一种新型c-Met抑制剂，可抑制c-Met的配体依赖性和配体依赖性活化，从而抑制其酪氨酸激酶活性。

靶点信息

c-Met
9 nM

溶解度 *

In vitro (25°C)	DMSO	0.22 mg/mL (0.57 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.08 mL	130.41 mL	260.82 mL
0.5 mM	5.22 mL	26.08 mL	52.16 mL
1 mM	2.61 mL	13.04 mL	26.08 mL
5 mM	0.52 mL	2.61 mL	5.22 mL

*The above data is based on the productmolecular weight 383.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10063
作用机制	Inhibitor (抑制剂)
M. Wt	383.4
Formula	C22H17N5O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1002304-34-8
Synonyms	AMG208, AMG-208
SMILES	COC1=CC2=NC=CC(=C2C=C1)OCC3=NN=C4N3N=C(C=C4)C5=CC=CC=C5