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AMG-458

目录号: A11055
c-Met 抑制剂
AMG-458 是一种强效的 c-Met 抑制剂,其 IC50 值为 60nM,并且对 VEGFR2 表现出选择性。
Grouped product items
规格 价格 库存 数量
2mg
¥210.00
现货
5mg
¥350.00
现货
10mg
¥595.00
现货
25mg
¥1,190.00
现货
50mg
¥1,750.00
现货
100mg
¥2,450.00
现货
200mg
¥3,430.00
现货
10mM * 1mL in DMSO
¥1,547.00
现货
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生物活性
Discription AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against VEGFR2.
Targets
Target Value
Cell Research
Cell Line Type Value Description References
产品信息
目录号 A11055
分子式 C30H29N5O5
分子量 539.6
CAS号 913376-83-7
SMILES CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC
其他名称 AMG458, AMG 458
储存条件

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据
In vitro (25°C) DMSO 18 mg/mL (33.35 mM)
Water Insoluble
Ethanol Insoluble
In vivo 15% Captisol+citrate vehicle 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.53 mL 92.66 mL 185.32 mL
0.5 mM 3.71 mL 18.53 mL 37.06 mL
1 mM 1.85 mL 9.27 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

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    C2

    V2

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