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AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
| In vitro | DMSO | 97 mg/mL (160.7 mM) | |
| Water | Insoluble | ||
| Ethanol | 97 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.57 mL | 82.84 mL | 165.68 mL |
| 0.5 mM | 3.31 mL | 16.57 mL | 33.14 mL |
| 1 mM | 1.66 mL | 8.28 mL | 16.57 mL |
| 5 mM | 0.33 mL | 1.66 mL | 3.31 mL |
*The above data is based on the productmolecular weight 603.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21162 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 603.59 |
| Formula | C32H28F3N5O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 473719-41-4 |
| Synonyms | AMG-487, AMG487 |
| SMILES | O=C(N([C@@H](C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5 |
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