AMG 487

Name: AMG 487
SKU: A21162
Price: 280 CNY
Rating: 5 (288 reviews)

目录号: A21162

CXCR3 拮抗剂

AMG 487 是一种口服活性的选择性 CXC趋化因子受体3 (CXCR3) 拮抗剂，能够抑制CXCL10和CXCL11与CXCR3的结合，其半抑制浓度（IC50）分别为8.0和8.2纳摩尔。

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Grouped product items
规格	价格	库存
1mg	¥280.00	现货
2mg	¥455.00	现货
5mg	¥770.00	现货
10mg	¥1,120.00	现货
25mg	¥1,925.00	现货
50mg	¥2,870.00	现货
100mg	¥4,270.00	现货
*10mM 1mL in DMSO**	¥1,050.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

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生物活性

Discription

AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.

Targets

Target	Value

产品信息

目录号	A21162
分子式	C32H28F3N5O4
分子量	603.59
CAS号	473719-41-4
SMILES	O=C(N([C@@H](C1=NC2=NC=CC=C2C(N1C3=CC=C(OCC)C=C3)=O)C)CC4=CC=CN=C4)CC5=CC=C(OC(F)(F)F)C=C5
其他名称	AMG-487, AMG487
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	97 mg/mL (160.7 mM)
	Water	Insoluble
	Ethanol	97 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.57 mL	82.84 mL	165.68 mL
0.5 mM	3.31 mL	16.57 mL	33.14 mL
1 mM	1.66 mL	8.28 mL	16.57 mL
5 mM	0.33 mL	1.66 mL	3.31 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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