AMPK

Inhibitory Selectivity

Catalog No.	Inhibitor Name	AMPK
A13720	Dorsomorphin 2HCl	**
A14312	WZ4003	****
A11970	Dorsomorphin	**
A16281	HTH-01-015	***
A11071	A 769662	*
A15815	ETC-1002

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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PF-06409577

Catalog No. A16801
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AMPK 激活剂

PF-06409577是口服生物可利用的AMPK激活剂，在TR-FRET试验中，对AMPK α1β1γ1的EC50为7 nM。在膜片钳试验（100 uM）中没有检测到对hERG的抑制作用，也不是人类主要细胞色素P450亚型微粒体活性的抑制剂（IC50>100 uM）。了解更多

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MK-3903

Catalog No. A17063
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AMPK 激活剂

MK-3903是有效的选择性AMPK激活剂（EC50 = 8 nM）。口服给药后，MK-3903在小鼠肝脏中表现出强大的靶标参与性，从而改善了小鼠的脂质代谢和胰岛素敏感性。了解更多

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A-769662

Catalog No. A11071
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AMPK 激活剂

A-769662是AMP激活的蛋白激酶（AMPK）的新激活剂。了解更多

Product Citations (4)

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- Daniel Missailidis, .et al. Dysregulated Provision of Oxidisable Substrates to the Mitochondria in ME/CFS Lymphoblasts, Int J Mol Sci., 2021, Feb; 22(4): 2046 PMID: 33669532
- Lieberthal W, .et al. AMPK-mediated activation of Akt protects renal tubular cells from stress-induced apoptosis in vitro and ameliorates ischemic AKI in vivo, Am J Physiol Renal Physiol, 2019, 2019 PMID: 30995114
- Kikuchi H, .et al. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease, Kidney Int, 2018, Nov 13. pii: S0085-2538(18)30635-5 PMID: 30455054
- Schneider H, .et al. AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle, Hypertension, 2015, Jul;66(1):108-16 PMID: 26034200
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Acadesine (Aicar,NSC 105823)

Catalog No. A10028
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AMPK 激活剂

Acadesine (Aicar,NSC 105823)是肝细胞和脂肪细胞中AMPK的选择性激活剂。了解更多

Product Citations (2)

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- R. Lim, .et al. Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators., Placenta, 2015, Apr;36(4):454-62 PMID: 25659498
- Stella Liong, .et al. Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women., J Physiol Biochem, 2015, Dec;71(4):703-17 PMID: 26407807
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ETC-1002

Catalog No. A15815
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ACL 抑制剂 and AMPK 激活剂

ETC-1002是一种新颖的，一流的可以降低LDL-C的小分子；肝AMP激活的蛋白激酶（AMPK）的激活剂;对肝ATP-柠檬酸裂解酶也具有有效的抑制活性（IC50 = 29 uM）。了解更多

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GSK621

Catalog No. A15896
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AMPK 激活剂

GSK621是有效的选择性AMPK激动剂。了解更多

Product Citations (1)

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- Harvey W. Smith, .et al. An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis, Nat Commun, 2019, 10, 2901(2019) PMID: 31263101
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YLF-466D

Catalog No. A16284
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AMPK 激活剂

YLF-466D是一种变构AMPK激活剂。了解更多

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ex229 (compound 991)

Catalog No. A16795
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AMPK 激活剂

ex229 (compound 991)是一种有效的AMPK活化剂，在活化AMPK方面比A769662的效力高5-10倍。了解更多

Product Citations (1)

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- CN Koyani, .et al. Empagliflozin Protects Heart From Inflammation and Energy Depletion via AMPK Activation, Pharmacol Res, 2020, May 17;158:104870 PMID: 32434052
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MK8722

Catalog No. A13392
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pan-AMPK activator

MK8722 is a potent and systemic pan-AMPK activator. 了解更多

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ZLN024

Catalog No. A21963
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AMPK allosteric activator

ZLN024 is an AMPK allosteric activator. 了解更多

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