Anacetrapib (MK-0859)

Name: Anacetrapib (MK-0859)
SKU: A11084

目录号: A11084

CETP 抑制剂

Anacetrapib (MK-0859) Chemical Structure

CAS NO. 875446-37-0

Anacetrapib (MK-0859)是一种有效的，选择性，可逆的rhCETP和突变CETP(C13S)抑制剂，IC50分别为7.9 nM和11.8 nM，提高HDL-C，降低LDL-C，不提高醛固酮和血压。

库存：现货

规格	价格	数量
5 mg	￥ 840.00
10 mg	￥ 1,400.00
50 mg	￥ 4,060.00
100 mg	￥ 6,160.00
10mM * 1mL in DMSO	￥ 1,484.00

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生物活性

Anacetrapib (MK-0859)是一种有效的，选择性，可逆的rhCETP和突变CETP(C13S)抑制剂，IC50分别为7.9 nM和11.8 nM，提高HDL-C，降低LDL-C，不提高醛固酮和血压。

溶解度 *

In vitro (25°C)	DMSO	108 mg/mL (169.41 mM)
	Water	Insoluble
	Ethanol	108 mg/mL (169.41 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.69 mL	78.43 mL	156.86 mL
0.5 mM	3.14 mL	15.69 mL	31.37 mL
1 mM	1.57 mL	7.84 mL	15.69 mL
5 mM	0.31 mL	1.57 mL	3.14 mL

*The above data is based on the productmolecular weight 637.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11084
作用机制	Inhibitor (抑制剂)
M. Wt	637.5
Formula	C30H25F10NO3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	875446-37-0
Synonyms	MK0859
SMILES	C[C@H]1[C@H](OC(=O)N1CC2=C(C=CC(=C2)C(F)(F)F)C3=CC(=C(C=C3OC)F)C(C)C)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F