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Anastrozole是第三代非甾体选择性芳香化酶抑制剂。与其他芳香酶抑制剂相比，它可能具有更高的选择性，没有任何内在的内分泌作用，并且对肾上腺类固醇的合成也没有明显的作用。
靶点信息
| Aromatase | ||||
| 15 nM |
| In vitro | DMSO | 57 mg/mL (194.29 mM) | |
| Water | Insoluble | ||
| Ethanol | 57 mg/mL (194.29 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.08 mL | 170.42 mL | 340.83 mL |
| 0.5 mM | 6.82 mL | 34.08 mL | 68.17 mL |
| 1 mM | 3.41 mL | 17.04 mL | 34.08 mL |
| 5 mM | 0.68 mL | 3.41 mL | 6.82 mL |
*The above data is based on the productmolecular weight 293.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10075 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 293.4 |
| Formula | C17H19N5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 120511-73-1 |
| Synonyms | Arimidex |
| SMILES | CC(C)(C#N)C1=CC(=CC(=C1)CN2C=NC=N2)C(C)(C)C#N |
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