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AP1903是具有均二聚活性的脂质渗透性他克莫司类似物。二聚体药物AP1903将人类蛋白质FKBP12（Fv）的类似物同二聚化，该类似物包含单个酸取代（Phe36Val），因此AP1903以低1000倍的亲和力与野生型FKBP12结合。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 7.08 mL | 35.42 mL | 70.84 mL |
| 0.5 mM | 1.42 mL | 7.08 mL | 14.17 mL |
| 1 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 5 mM | 0.14 mL | 0.71 mL | 1.42 mL |
*The above data is based on the productmolecular weight 1411.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13519 |
|---|---|
| M. Wt | 1411.63 |
| Formula | C78H98N4O20 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 195514-63-7 |
| Synonyms | AP 1903, AP-1903 |
| SMILES | CC[C@@H](C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCC[C@H]2C(=O)O[C@H](CCC3=CC(=C(C=C3)OC)OC)C4=CC(=CC=C4)OCC(=O)NCCNC(=O)COC5=CC=CC(=C5)[C@@H](CCC6=CC(=C(C=C6)OC)OC)OC(=O)[C@@H]7CCCCN7C(=O)[C@@H](CC)C8=CC(=C(C(=C8)OC)OC)OC |
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