ALK-IN-1 (Brigatinib analog, AP26113 analog)

Name: ALK-IN-1 (Brigatinib analog, AP26113 analog)
SKU: A11948
Price: 245 CNY
Rating: 5 (288 reviews)

目录号: A11948

ALK 抑制剂

ALK-IN-1，一种 AP26113 的类似物，是一种口服可用的、强效的、选择性的 ALK 抑制剂，对野生型的效力为 0.62 nM，并且对包括对克唑替尼耐药的 L1196M 突变株在内的广泛突变体具有活性。

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ALK-IN-1 (Brigatinib analog, AP26113 analog)

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥385.00	现货
25mg	¥630.00	现货
50mg	¥980.00	现货
100mg	¥1,680.00	现货
200mg	¥2,520.00	现货
500mg	¥4,130.00	现货
*10mM 1mL in DMSO**	¥840.00	现货
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Data Sheet

SDS

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生物活性

Discription

ALK-IN-1, an analog of AP26113, is an orally-available, potent, and selective inhibitor of ALK with a potency of 0.62 nM against wild-type and activity against a wide range of mutants, including the crizotinib-resistant L1196M line.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11948
分子式	C26H34ClN6O2P
分子量	529.01
CAS号	1197958-12-5
SMILES	CN(C)C1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4P(=O)(C)C)Cl)OC
其他名称	AP-26113
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	40 mg/mL (75.61 mM)
	Water	Insoluble
	Ethanol	93 mg/mL (175.8 mM)
In vivo	NMP+PEG300 (10+90, v+v)	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.9 mL	94.52 mL	189.03 mL
0.5 mM	3.78 mL	18.9 mL	37.81 mL
1 mM	1.89 mL	9.45 mL	18.9 mL
5 mM	0.38 mL	1.89 mL	3.78 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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