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Apoptosis Activator 2 强烈诱导caspase-3激活，PARP裂解和DNA片段化，导致细胞破坏（依赖Apaf-1），IC50为约4μM，对HMEC，PREC或MCF-10A细胞无效。
靶点信息
| Caspase-3 | ||||
| In vitro | DMSO | 53 mg/mL (173.12 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.67 mL | 163.35 mL | 326.69 mL |
| 0.5 mM | 6.53 mL | 32.67 mL | 65.34 mL |
| 1 mM | 3.27 mL | 16.33 mL | 32.67 mL |
| 5 mM | 0.65 mL | 3.27 mL | 6.53 mL |
*The above data is based on the productmolecular weight 306.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11944 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 306.1 |
| Formula | C15H9Cl2NO2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 79183-19-0 |
| SMILES | C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl |
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