Aprepitant (MK-0869)

Name: Aprepitant (MK-0869)
SKU: A10083
Price: 175 CNY
Rating: 5 (2 reviews)

目录号: A10083

neurokinin-1 receptor 拮抗剂

2 篇发表文献

Aprepitant 被分类为 NK1拮抗剂。研究显示，Aprepitant 通过阻止P物质降落在大脑神经元的受体上，能够抑制由细胞毒性化疗药物引起的急性和延迟性呕吐。它还被发现可以增强5-HT3受体拮抗剂奥坦西龙和皮质类固醇地塞米松的活性，这两种药物也用于预防化疗引起的恶心和呕吐。

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Grouped product items
规格	价格	库存
2mg	¥175.00	现货
5mg	¥280.00	现货
10mg	¥350.00	现货
25mg	¥455.00	现货
50mg	¥525.00	现货
100mg	¥630.00	现货
200mg	¥770.00	现货
500mg	¥980.00	现货
*10mM 1mL in DMSO**	¥350.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Aprepitant (MK-0869)发表的2篇文献

Maya Tokumoto, .et al. , Connect Tissue Res, 2022, Jul 20;1-11 PMID: 35856812

Kodji X, .et al. , FASEB J, 2018, Sep 11:fj201800395RR PMID: 30204499

生物活性

Discription

Aprepitant is classified as an NK1 antagonist. Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brains neurons. It has also been shown to increase the activity of the 5-HT3 receptor antagonists ondansetron and the corticosteroid dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10083
分子式	C23H21F7N4O3
分子量	534.4
CAS号	170729-80-3
SMILES	C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F
其他名称	L-754030, Emend
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	96 mg/mL (179.63 mM)
	Water	Insoluble
	Ethanol	14 mg/mL (26.19 mM)
In vivo	5% DMSO+corn oil	12 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.71 mL	93.56 mL	187.13 mL
0.5 mM	3.74 mL	18.71 mL	37.43 mL
1 mM	1.87 mL	9.36 mL	18.71 mL
5 mM	0.37 mL	1.87 mL	3.74 mL

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