Aprepitant (MK-0869)

目录号: A10083

neurokinin-1 receptor 拮抗剂

Aprepitant (MK-0869)

Aprepitant (MK-0869) Chemical Structure

CAS NO. 170729-80-3

Aprepitant (MK-0869)被归类为NK1拮抗剂。已经显示,阿瑞匹坦通过阻止P物质降落在大脑神经元受体上,从而抑制细胞毒性化疗药物引起的急性呕吐和延迟呕吐。还显示出它能增加5-HT3受体拮抗剂恩丹西酮和皮质类固醇地塞米松的活性,它们也可用于预防化学疗法引起的恶心和呕吐。

库存: 现货

规格 价格 数量
2 mg
¥ 210.00
5 mg
¥ 350.00
10 mg
¥ 420.00
25 mg
¥ 490.00
10mM * 1mL in DMSO
¥ 973.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Aprepitant (MK-0869)被归类为NK1拮抗剂。已经显示,阿瑞匹坦通过阻止P物质降落在大脑神经元受体上,从而抑制细胞毒性化疗药物引起的急性呕吐和延迟呕吐。还显示出它能增加5-HT3受体拮抗剂恩丹西酮和皮质类固醇地塞米松的活性,它们也可用于预防化学疗法引起的恶心和呕吐。
靶点信息
Neurokinin-1 receptor (Cell-free assay)
0.1 nM
In vitro (25°C) DMSO 96 mg/mL (179.63 mM)
Water Insoluble
Ethanol 14 mg/mL (26.19 mM)
In vivo 5% DMSO+corn oil 12 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.71 mL 93.56 mL 187.13 mL
0.5 mM 3.74 mL 18.71 mL 37.43 mL
1 mM 1.87 mL 9.36 mL 18.71 mL
5 mM 0.37 mL 1.87 mL 3.74 mL

*The above data is based on the productmolecular weight 534.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10083
作用机制 Antagonist (拮抗剂)
M. Wt 534.4
Formula C23H21F7N4O3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 170729-80-3
Synonyms MK0869, MK-869, L-754030, Emend
SMILES C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)NN3)C4=CC=C(C=C4)F

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