Apalutamide (ARN-509)

Name: Apalutamide (ARN-509)
SKU: A11923
Price: 280 CNY
Rating: 5 (1 reviews)

目录号: A11923

Androgen Receptor 抑制剂

1 篇发表文献

ARN-509 是一种具有潜在抗肿瘤活性的雄激素受体拮抗剂。ARN-509 与靶组织中的雄激素受体（AR）结合，从而阻止雄激素诱导的受体激活，并促进形成无法转移到细胞核的非活性复合物。这阻止了与 AR-响应基因的结合和转录。

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Grouped product items
规格	价格	库存
2mg	¥280.00	现货
5mg	¥455.00	现货
10mg	¥805.00	现货
25mg	¥1,645.00	现货
50mg	¥2,415.00	现货
100mg	¥4,095.00	现货
*10mM 1mL in DMSO**	¥455.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Apalutamide (ARN-509)发表的1篇文献

Frédérique Mittler, .et al. , Front Oncol, 2017, 7: 293 PMID: 29322028

生物活性

Discription

ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11923
分子式	C21H15F4N5O2S
分子量	477.4
CAS号	956104-40-8
SMILES	CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C(=C4)C(F)(F)F)C#N)F
其他名称	ARN509
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	18 mg/mL (37.7 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (10.47 mM)
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.95 mL	104.73 mL	209.47 mL
0.5 mM	4.19 mL	20.95 mL	41.89 mL
1 mM	2.09 mL	10.47 mL	20.95 mL
5 mM	0.42 mL	2.09 mL	4.19 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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