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AS-35 is an orally effective, potent and selective antagonist of leukotrienes, antagonizes LTC4-, LTD4 and LTE4-induced contractions of the ileum with IC50 values of 8 nM, 4 nM and 3 nM, respectively, and has antiallergic activities.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.79 mL | 118.93 mL | 237.86 mL |
| 0.5 mM | 4.76 mL | 23.79 mL | 47.57 mL |
| 1 mM | 2.38 mL | 11.89 mL | 23.79 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
*The above data is based on the productmolecular weight 420.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A19409 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 420.42 |
| Formula | C21H20N6O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 108427-72-1 |
| Synonyms | AS35, AS 35 |
| SMILES | O=C1C(C2=NN=NN2)=CN=C3N1C=CC=C3COC4=CC=C(C(C)=O)C(O)=C4CCC |
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