AS-604850
目录号: A11197
PI3K Inhibitor
AS-604850 抑制了 MCP-1 介导的单核细胞趋化作用，其 IC50 值为 21 微摩尔，并且在小鼠白细胞趋化模型中减少了 RANTES 引起的腹膜中性粒细胞募集，ED50 值为 42.4 毫克/千克。
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生物活性
| Discription | AS-604850 inhibited MCP-1-mediated monocyte chemotaxis with an IC50 value of 21 µM and reduced RANTES-induced peritoneal neutrophil recruitment in a murine model of leukocyte chemotaxis with an ED50 value of 42.4 mg/kg. |
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产品信息
| 目录号 | A11197 |
|---|---|
| 分子式 | C11H5F2NO4S |
| 分子量 | 285.22 |
| CAS号 | 648449-76-7 |
| SMILES | C1=CC2=C(C=C1/C=C\3/C(=O)NC(=O)S3)OC(O2)(F)F |
| 其他名称 | AS604850 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 49 mg/mL (171.79 mM) | |
| Water | Insoluble | ||
| Ethanol | 4 mg/mL (14.02 mM) | ||
| In vivo | 0.5% CMC+0.25% Tween 80 | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.06 mL | 175.3 mL | 350.61 mL |
| 0.5 mM | 7.01 mL | 35.06 mL | 70.12 mL |
| 1 mM | 3.51 mL | 17.53 mL | 35.06 mL |
| 5 mM | 0.7 mL | 3.51 mL | 7.01 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 648449-76-7 | 648449-76-7 供应商 | 648449-76-7 花费 | 648449-76-7 生产商 | 订购 648449-76-7 | 648449-76-7 代理商