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AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.35 mL | 111.74 mL | 223.47 mL |
| 0.5 mM | 4.47 mL | 22.35 mL | 44.69 mL |
| 1 mM | 2.23 mL | 11.17 mL | 22.35 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.47 mL |
*The above data is based on the productmolecular weight 447.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18630 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 447.48 |
| Formula | C25H25N3O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2148339-28-8 |
| Synonyms | AS 2717638, AS-2717638 |
| SMILES | O=C1N(C2=NOC3=C2C=C(C)C=C3)C=C(C(N4CCCCC4)=O)C5=C1C=C(OC)C(OC)=C5 |
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