Asciminib
目录号: A19658
Bcr-Abl inhibitor
Asciminib（ABL001）是一种强效且选择性的异构Bcr-Abl抑制剂；对Ba/F3细胞的生长抑制作用的IC50为0.25 nM。
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生物活性
| Discription | Asciminib (ABL001) is a potent and selective allosteric Bcr-Abl inhibitor; inhibits Ba/F3 cells grown with an IC50 of 0.25 nM. | |||||
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| Cell Research |
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产品信息
| 目录号 | A19658 |
|---|---|
| 分子式 | C20H18ClF2N5O3 |
| 分子量 | 449.84 |
| CAS号 | 1492952-76-7 |
| SMILES | O=C(C1=CC(C2=NNC=C2)=C(N3C[C@H](O)CC3)N=C1)NC4=CC=C(OC(F)(Cl)F)C=C4 |
| 其他名称 | ABL001, ABL 001, ABL-001 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 76 mg/mL (168.94 mM) | |
| Ethanol | 76 mg/mL (168.94 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.23 mL | 111.15 mL | 222.3 mL |
| 0.5 mM | 4.45 mL | 22.23 mL | 44.46 mL |
| 1 mM | 2.22 mL | 11.12 mL | 22.23 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.45 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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