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ASP3026是ALK激酶的新型选择性抑制剂。ASP3026在Tyr激酶组中有效抑制ALK激酶活性，并且比克唑替尼更具选择性。
靶点信息
| ALK | ||||
| 3.5 nM |
| In vitro | DMSO | 13 mg/mL (22.38 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.22 mL | 86.1 mL | 172.21 mL |
| 0.5 mM | 3.44 mL | 17.22 mL | 34.44 mL |
| 1 mM | 1.72 mL | 8.61 mL | 17.22 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
*The above data is based on the productmolecular weight 580.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11773 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 580.7 |
| Formula | C29H40N8O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1097917-15-1 |
| Synonyms | ASP 3026, ASP-3026 |
| SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC=NC(=N2)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC |
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