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ASTX-660

产品详情

生物活性

ASTX660是X染色体连锁的凋亡蛋白抑制剂（XIAP）和细胞IAP 1（cIAP1）的口服生物利用型非拟肽拮抗剂，具有潜在的抗肿瘤和促凋亡活性。1799328-86-1 (free base) 1799328-50-9 (HCl) 1799328-90-7 (mesylate) 1799328-88-3 (sulfate)

溶解度 *

In vitro	DMSO	93 mg/mL (172.32 mM)
	Water	Insoluble
	Ethanol	93 mg/mL (172.32 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.53 mL	92.65 mL	185.29 mL
0.5 mM	3.71 mL	18.53 mL	37.06 mL
1 mM	1.85 mL	9.26 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL

*The above data is based on the productmolecular weight 539.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A16996
作用机制	Inhibitor (抑制剂)
M. Wt	539.69
Formula	C30H42FN5O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1799328-86-1
Synonyms	ASTX660, ASTX 660
SMILES	OCC1=NC2=C(N(CC2(C)C)C(CN3[C@@H](CN4[C@H](C)COCC4)CN[C@H](C)C3)=O)C=C1CC5=CC=C(F)C=C5