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AT-406 (SM-406,ARRY-334543)是IAP家族蛋白质的口服生物利用抑制剂，具有潜在的凋亡诱导和抗肿瘤活性。AT-406选择性抑制IAP蛋白的生物学活性，包括X染色体连锁IAP（XIAP），细胞IAP 1（c-IAP1）和2（c-IAP2）和黑色素瘤凋亡抑制蛋白（ML-IAP）。
| In vitro (25°C) | DMSO | 85 mg/mL (151.32 mM) | |
| Water | Insoluble | ||
| Ethanol | 85 mg/mL (151.32 mM) | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.8 mL | 89.01 mL | 178.03 mL |
| 0.5 mM | 3.56 mL | 17.8 mL | 35.61 mL |
| 1 mM | 1.78 mL | 8.9 mL | 17.8 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.56 mL |
*The above data is based on the productmolecular weight 561.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11163 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 561.71 |
| Formula | C32H43N5O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1071992-99-8 |
| Synonyms | AT406, SM-406, ARRY-334543 |
| SMILES | C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C)NC |
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