Onalespib (AT13387)

Name: Onalespib (AT13387)
SKU: A11062

目录号: A11062

HSP90 抑制剂

Product Citations (3)

Onalespib (AT13387) Chemical Structure

CAS NO. 912999-49-6

Onalespib (AT13387)是Hsp90的靶向抑制剂，可抑制其伴侣功能并促进涉及肿瘤细胞增殖和存活的致癌信号蛋白的降解。

库存：现货

规格	价格	数量
5 mg	￥ 630.00
10 mg	￥ 1,050.00
50 mg	￥ 2,450.00
100 mg	￥ 3,990.00
10mM * 1mL in DMSO	￥ 665.00

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生物活性

Onalespib (AT13387)是Hsp90的靶向抑制剂，可抑制其伴侣功能并促进涉及肿瘤细胞增殖和存活的致癌信号蛋白的降解。

靶点信息

HSP90 (Cell-free assay)
18 nM

溶解度 *

In vitro (25°C)	DMSO	22 mg/mL (53.72 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+ddH2O (prepare before use)	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.42 mL	122.1 mL	244.2 mL
0.5 mM	4.88 mL	24.42 mL	48.84 mL
1 mM	2.44 mL	12.21 mL	24.42 mL
5 mM	0.49 mL	2.44 mL	4.88 mL

*The above data is based on the productmolecular weight 409.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11062
作用机制	Inhibitor (抑制剂)
M. Wt	409.5
Formula	C24H31N3O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	912999-49-6
Synonyms	AT-13387
SMILES	CC(C)C1=C(C=C(C(=C1)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C)O)O