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Atrasentan是一种实验药物，正在研究中，用于治疗各种类型的癌症，包括非小细胞肺癌。它是对A型亚型（ETA）有选择性的内皮素受体拮抗剂,对ETA的IC50为0.0551 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.58 mL | 97.92 mL | 195.84 mL |
| 0.5 mM | 3.92 mL | 19.58 mL | 39.17 mL |
| 1 mM | 1.96 mL | 9.79 mL | 19.58 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.92 mL |
*The above data is based on the productmolecular weight 510.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13779 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 510.62 |
| Formula | C29H38N2O6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 173937-91-2 |
| Synonyms | (+)-A 127722, ABT-627, A 127722, ABT 627 |
| SMILES | CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1C2=CC=C(C=C2)OC)C(=O)O)C3=CC4=C(C=C3)OCO4 |
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