Auristatin F
目录号: A21265
cytotoxic tubulin modifier
Auristatin F 是一种具有强效和选择性抗肿瘤活性的细胞毒性微管蛋白修饰剂;是 MMAF 类似物和抗体药物偶联物中的细胞毒素。Auristatin F 通过阻断微管蛋白的聚合来抑制细胞分裂。
Discription | Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAF analog and cytotoxin in Antibody-drug conjugates. Auristatin F inhibits cell division by blocking the polymerisation of tubulin. |
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目录号 | A21265 |
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分子式 | C40H67N5O8 |
分子量 | 745.99 |
CAS号 | 163768-50-1 |
SMILES | CC(C)[C@H](N(C)C)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)OC)C)=O)C(C)C)=O |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2