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TC-S 7010 (Aurora A Inhibitor I)是Aurora A激酶（AurA）的有效和选择性抑制剂，IC50值为3.4 nM（Aurora A），对Aurora B具有极高的选择性1000倍； 用于研究Aurora A激酶的细胞作用的有用工具化合物。
靶点信息
| Aurora A (Cell-free assay) | Aurora C (Cell-free assay) | Aurora B (Cell-free assay) | ||
| 3.4 nM | 432 nM | 3.4 μM |
| In vitro (25°C) | DMSO | 105 mg/mL (178.54 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5%DMSO+40%PEG300+5%Tween80+50%ddH2O | 1.18 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17 mL | 85.02 mL | 170.04 mL |
| 0.5 mM | 3.4 mL | 17 mL | 34.01 mL |
| 1 mM | 1.7 mL | 8.5 mL | 17 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.4 mL |
*The above data is based on the productmolecular weight 588.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10100 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 588.1 |
| Formula | C31H31ClFN7O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1158838-45-9 |
| Synonyms | TC-S7010, TC-S-7010, TCS7010, TCS-7010 |
| SMILES | CCN1CCN(CC1)C(=O)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5Cl)F |
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