AUY922 (Luminespib, NVP-AUY922)

Name: AUY922 (Luminespib, NVP-AUY922)
SKU: A10659
Price: 245 CNY
Rating: 5 (3 reviews)

目录号: A10659

HSP90 抑制剂

3 篇发表文献

AUY922（NVP-AUY922）是一种高效的口服 Hsp90 抑制剂，其在 Hsp90 FP 结合实验中的 IC50 为21 nM，并且能够抑制多种人类癌症细胞系在体外的增殖，平均 GI50 为9 nM。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥455.00	现货
25mg	¥945.00	现货
50mg	¥1,575.00	现货
100mg	¥2,415.00	现货
200mg	¥3,920.00	现货
500mg	¥6,370.00	现货
*10mM 1mL in DMSO**	¥350.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用AUY922 (Luminespib, NVP-AUY922)发表的3篇文献

Celia Rouges, .et al. , Microorganisms, 2023, Nov 22;11(12):2837 PMID: 38137982

Haruka Wakasa, .et al. , J Mammary Gland Biol Neoplasia, 2022, Jun;27(2):155-170 PMID: 35581442

Hiroki Murano, .et al. , Plant Biotechnol Rep, 2017, 11:107-113

生物活性

Discription

AUY922 (NVP-AUY922) is highly potent and oral inhibitor of Hsp90 with IC50=21 nM in Hsp90 FP binding assay and inhibits proliferation of various human cancer cell lines in vitro, with GI50 average 9 nM.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10659
分子式	C26H31N3O5
分子量	465.5
CAS号	747412-49-3
SMILES	CCNC(=O)C1=C(/C(=C/2\C=C(C(=CC2=O)O)C(C)C)/ON1)C3=CC=C(C=C3)CN4CCOCC4
其他名称	VER-52296,
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 86 mg/mL (184.72 mM)
	Water	Insoluble
	Ethanol	29 mg/mL (62.28 mM)
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.48 mL	107.41 mL	214.82 mL
0.5 mM	4.3 mL	21.48 mL	42.96 mL
1 mM	2.15 mL	10.74 mL	21.48 mL
5 mM	0.43 mL	2.15 mL	4.3 mL

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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