Avasimibe (CI-1011)

Name: Avasimibe (CI-1011)
SKU: A10102

目录号: A10102

CYP17 抑制剂

Product Citations (1)

Avasimibe (CI-1011) Chemical Structure

CAS NO. 166518-60-1

Avasimibe (CI-1011)是口服可生物利用的酰基辅酶A：胆固醇O-酰基转移酶（ACAT）抑制剂，IC50分别为2.9 μM， 13.9 μM和26.5 μM。

库存：现货

规格	价格	数量
10 mg	￥ 350.00
50 mg	￥ 1,260.00
100 mg	￥ 2,240.00
200 mg	￥ 3,640.00
10mM * 1mL in DMSO	￥ 588.00

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产品详情

生物活性

Avasimibe (CI-1011)是口服可生物利用的酰基辅酶A：胆固醇O-酰基转移酶（ACAT）抑制剂，IC50分别为2.9 μM， 13.9 μM和26.5 μM。

靶点信息

CYP2C9	ACAT	CYP1A2	CYP2C19
2.9 μM	3.3 μM	13.9 μM	26.5 μM

溶解度 *

In vitro (25°C)	DMSO	96 mg/mL (191.34 mM)
	Water	Insoluble
	Ethanol	8 mg/mL (15.94 mM)
In vivo	2% DMSO+corn oil	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.93 mL	99.66 mL	199.32 mL
0.5 mM	3.99 mL	19.93 mL	39.86 mL
1 mM	1.99 mL	9.97 mL	19.93 mL
5 mM	0.4 mL	1.99 mL	3.99 mL

*The above data is based on the productmolecular weight 501.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10102
作用机制	Inhibitor (抑制剂)
M. Wt	501.7
Formula	C29H43NO4S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	166518-60-1
Synonyms	CI-1011, CI1011, PD 148515
SMILES	CC(C)C1=C(C(=CC=C1)C(C)C)OS(=O)(=O)NC(=O)CC2=C(C=C(C=C2C(C)C)C(C)C)C(C)C