AVN-944

Name: AVN-944
SKU: A13652
Price: 315 CNY
Rating: 5 (4 reviews)

目录号: A13652

IMPDH inhibitor

4 篇发表文献

AVN-944（也称为 VX-944）是一种有效的口服抑制剂，专门针对并抑制 IMPDH（肌苷酸脱氢酶）。这种酶在从头合成鸟嘌呤核苷酸中起着关键的限速作用。此外，AVN-944 对抗 RNA 的合成在黄病毒中也显示出效果，有效预防黄病毒感染。AVN-944 展示了广泛的抗癌特性，被用于多发性骨髓瘤（MM）和急性髓细胞性白血病（AML）的相关研究。

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Grouped product items
规格	价格	库存
1mg	¥315.00	现货
5mg	¥560.00	现货
10mg	¥910.00	现货
25mg	¥2,030.00	现货
50mg	¥3,290.00	现货
100mg	¥4,760.00	现货
*10mM 1mL in DMSO**	¥630.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用AVN-944发表的4篇文献

Kevin Chiem, .et al. , Microbiol Spectr, 2023, Aug 17;11(4):e0474522 PMID: PMC10434227

Desarey Morales Vasquez, .et al. , Viruses, 2020, Sep; 12(9): 1041 PMID: 32961956

Park JG, .et al. , J Virol, 2020, Mar 17;94(7) PMID: 31941776

Dunham EC, .et al. , Antiviral Res, 2018, Sep;157:140-150 PMID: 30031760

生物活性

Discription

AVN-944 (also known as VX-944) serves as an effective oral inhibitor, specifically targeting and inhibiting IMPDH (inosine monophosphate dehydrogenase). This enzyme plays a crucial role as a rate-limiting factor in the synthesis of guanine nucleotides from scratch. Additionally, AVN-944 acts against the synthesis of RNA in arenaviruses, effectively preventing arenavirus infections. Demonstrating a wide spectrum of anti-cancer properties, AVN-944 is utilized in research related to multiple myeloma (MM) and acute myeloid leukemia (AML).

产品信息

目录号	A13652
分子式	C25H27N5O5
分子量	477.51
CAS号	297730-17-7
SMILES	CC[C@H](CC#N)OC(=O)N[C@@H](C)C1=CC(=CC=C1)NC(=O)NC2=CC(=C(C=C2)C3=CN=CO3)OC
其他名称	AVN 944, AVN944, VX-944, VX 944, VX944
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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