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AZ-960

目录号: A10104

JAK2 抑制剂

AZ-960 是一种强效、选择性和与ATP竞争的 JAK2抑制剂,在体外对 JAK2激酶 的抑制常数(Ki)为0.45 nM,并且能在成人T细胞白血病(ATL)细胞中诱导生长停滞和凋亡。
Grouped product items
规格 价格 库存 数量
1mg
¥420.00
现货
2mg
¥525.00
现货
5mg
¥840.00
现货
10mg
¥1,400.00
现货
25mg
¥2,625.00
现货
50mg
¥3,920.00
现货
100mg
¥7,350.00
现货
10mM * 1mL in DMSO
¥630.00
现货
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重要通知:仅供研究使用。我们不向患者销售。

顾客使用 Adooq 产品发表的高质量科研文献
Adooq用户使用AZ-960发表的1篇文献
  • Rongshou Wu, .et al. , Sci Rep, 2023, 13: 16998 PMID: 37813900
  • 生物活性
    Discription AZ-960 is a potent, selective and ATP competitive JAK2 inhibitor that inhibits JAK2 kinase with a Ki of 0.45 nM in vitro and induces growth arrest and apoptosis in adult T-cell leukemia (ATL) cell.
    Targets
    Target Value
    Cell Research
    Cell Line Type Value Description References
    产品信息
    目录号 A10104
    分子式 C18H16F2N6
    分子量 354.4
    CAS号 905586-69-8
    SMILES CC1=CC(=NN1)NC2=C(C=C(C(=N2)N[C@@H](C)C3=CC=C(C=C3)F)C#N)F
    储存条件

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    溶解性数据
    In vitro DMSO 70 mg/mL (197.54 mM)
    Water Insoluble
    Ethanol 3 mg/mL (8.46 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 28.22 mL 141.08 mL 282.17 mL
    0.5 mM 5.64 mL 28.22 mL 56.43 mL
    1 mM 2.82 mL 14.11 mL 28.22 mL
    5 mM 0.56 mL 2.82 mL 5.64 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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