AZ304

Name: AZ304
SKU: A17225
Price: 140 CNY
Rating: 5 (288 reviews)

目录号: A17225

dual BRAF 抑制剂

AZ304 是一种强效的双重 BRAF 抑制剂，针对野生型 BRAF 和 V600E 突变型 BRAF 的激酶结构域。AZ304 对野生型和 V600E 突变型 的丝氨酸/苏氨酸蛋白激酶 BRAF 表现出强效的抑制作用，其 IC50 值分别为 79 nM 和 38 nM。

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Grouped product items
规格	价格	库存
5mg	¥140.00	现货
10mg	¥210.00	现货
25mg	¥350.00	现货
50mg	¥630.00	现货
100mg	¥1,050.00	现货
*10mM 1mL in DMSO**	¥210.00	现货
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Data Sheet

SDS

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生物活性

Discription

AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively.

Targets

Target	Value

产品信息

目录号	A17225
分子式	C27H25N5O2
分子量	451.53
CAS号	942507-42-8
SMILES	O=C(NC1=CC=C(C)C(NC2=C3C=CC(OC)=CC3=NC=N2)=C1)C4=CC=CC(C(C)(C#N)C)=C4
其他名称	AZ-304; AZ 304;
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	81 mg/mL (179.39 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (11.07 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.15 mL	110.73 mL	221.47 mL
0.5 mM	4.43 mL	22.15 mL	44.29 mL
1 mM	2.21 mL	11.07 mL	22.15 mL
5 mM	0.44 mL	2.21 mL	4.43 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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