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AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively.
| In vitro | DMSO | 81 mg/mL (179.39 mM) | |
| Water | Insoluble | ||
| Ethanol | 5 mg/mL (11.07 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.15 mL | 110.73 mL | 221.47 mL |
| 0.5 mM | 4.43 mL | 22.15 mL | 44.29 mL |
| 1 mM | 2.21 mL | 11.07 mL | 22.15 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.43 mL |
*The above data is based on the productmolecular weight 451.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17225 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 451.53 |
| Formula | C27H25N5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 942507-42-8 |
| Synonyms | AZ-304; AZ 304; |
| SMILES | O=C(NC1=CC=C(C)C(NC2=C3C=CC(OC)=CC3=NC=N2)=C1)C4=CC=CC(C(C)(C#N)C)=C4 |
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