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AZ628是一种RAF抑制剂，IC50值：BRAF V600E和野生型CRAF约为30 nM，野生型BRAF约为100 nM。
靶点信息
| C-Raf-1 (Cell-free assay) | B-Raf (V600E) (Cell-free assay) | B-Raf (Cell-free assay) | ||
| 29 nM | 34 nM | 105 nM |
| In vitro (25°C) | DMSO | 80 mg/mL (177.17 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+40% PEG 300+2% Tween 80+ddH2O | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.15 mL | 110.74 mL | 221.48 mL |
| 0.5 mM | 4.43 mL | 22.15 mL | 44.3 mL |
| 1 mM | 2.21 mL | 11.07 mL | 22.15 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.43 mL |
*The above data is based on the productmolecular weight 451.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11063 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 451.5 |
| Formula | C27H25N5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 878739-06-1 |
| Synonyms | AZ-628 |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C |
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