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AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.51 mL | 102.57 mL | 205.14 mL |
| 0.5 mM | 4.1 mL | 20.51 mL | 41.03 mL |
| 1 mM | 2.05 mL | 10.26 mL | 20.51 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.1 mL |
*The above data is based on the productmolecular weight 487.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20045 |
|---|---|
| M. Wt | 487.47 |
| Formula | C24H24F3N5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1092453-15-0 |
| Synonyms | AZD8529, AZD 8529 |
| SMILES | O=C1C2=C(C)C=C(C3=NC(CN4CCNCC4)=NO3)C=C2CN1CC5=CC=C(OC(F)(F)F)C=C5 |
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