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AZD1152-HQPA (Barasertib)

AZD1152-HQPA (Barasertib)

Name: AZD1152-HQPA (Barasertib)
SKU: A10109

目录号: A10109

Aurora Kinase B 抑制剂

Product Citations (2)

AZD1152-HQPA (Barasertib) Chemical Structure

CAS NO. 722544-51-6

AZD1152-HQPA (Barasertib)是Aurora B的高效抑制剂，Ki值分别为0.36（Aurora B）和1369 nM（Aurora A），与一组其他50种激酶相比具有很高的特异性。

库存：现货

规格	价格	数量
5 mg	￥ 315.00
10 mg	￥ 441.00
50 mg	￥ 1,827.00
100 mg	￥ 3,276.00
10mM * 1mL in DMSO	￥ 560.00

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生物活性

AZD1152-HQPA (Barasertib)是Aurora B的高效抑制剂，Ki值分别为0.36（Aurora B）和1369 nM（Aurora A），与一组其他50种激酶相比具有很高的特异性。

靶点信息

Aurora B (Cell-free assay)	Aurora A (Cell-free assay)
0.37 nM	1368 nM

溶解度 *

In vitro (25°C)	DMSO	93 mg/mL (183.23 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (5.91 mM)
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	6 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.7 mL	98.48 mL	196.97 mL
0.5 mM	3.94 mL	19.7 mL	39.39 mL
1 mM	1.97 mL	9.85 mL	19.7 mL
5 mM	0.39 mL	1.97 mL	3.94 mL

*The above data is based on the productmolecular weight 507.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10109
作用机制	Inhibitor (抑制剂)
M. Wt	507.7
Formula	C26H30FN7O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	722544-51-6
Synonyms	Barasertib
SMILES	CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO