AZD2014 (Vistusertib)

Name: AZD2014 (Vistusertib)
SKU: A11303

目录号: A11303

mTORC1/2 抑制剂

Product Citations (1)

AZD2014 (Vistusertib) Chemical Structure

CAS NO. 1009298-59-2

Vistusertib (AZD2014)是一种新型mTOR抑制剂，无细胞试验中IC50为2.8 nM；对多种PI3K亚型(α/β/γ/δ)具有较高选择性。浓度为1 μM时，对大多数激酶无或有微弱结合力。

库存：现货

规格	价格	数量
5 mg	￥ 490.00
10 mg	￥ 840.00
25 mg	￥ 1,400.00
50 mg	￥ 1,890.00
10mM * 1mL in DMSO	￥ 385.00

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产品详情

生物活性

靶点信息

mTOR (Cell-free assay)	P-Akt (S473) (Cell-free assay)	pS6 (S235/236) (Cell-free assay)
2.8 nM	80 nM	200 nM

溶解度 *

In vitro (25°C)	DMSO	32 mg/mL (69.18 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.62 mL	108.11 mL	216.22 mL
0.5 mM	4.32 mL	21.62 mL	43.24 mL
1 mM	2.16 mL	10.81 mL	21.62 mL
5 mM	0.43 mL	2.16 mL	4.32 mL

*The above data is based on the productmolecular weight 462.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11303
作用机制	Inhibitor (抑制剂)
M. Wt	462.5
Formula	C25H30N6O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1009298-59-2
Synonyms	AZD-2014
SMILES	C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOC[C@@H]5C