AZD2858
目录号: A13060
GSK-3β 抑制剂
AZD2858 是一种选择性的 GSK-3 抑制剂，其 IC50 为 68 nM，能激活 Wnt 信号通路，在大鼠中增加骨量。
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生物活性
| Discription | AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats. | |||||
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| Cell Research |
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产品信息
| 目录号 | A13060 |
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| 分子式 | C21H23N7O3S |
| 分子量 | 453.52 |
| CAS号 | 486424-20-8 |
| SMILES | CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(C(=N3)C(=O)NC4=CN=CC=C4)N |
| 其他名称 | AZD-2858, AZD 2858 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 6 mg/mL (13.23 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.05 mL | 110.25 mL | 220.5 mL |
| 0.5 mM | 4.41 mL | 22.05 mL | 44.1 mL |
| 1 mM | 2.2 mL | 11.02 mL | 22.05 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.41 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 486424-20-8 | 486424-20-8 供应商 | 486424-20-8 花费 | 486424-20-8 生产商 | 订购 486424-20-8 | 486424-20-8 代理商