微信关注
Total item
Cart Subtotal
￥ 0.00 产品详情
AZD4547是一种有效，选择性和口服活性的pan-FGFR抑制剂，对于FGFR1、2、3和4的IC50分别为0.2、2.5、1.8和165 nM。
Targets
| Target | Value |
|---|---|
| FGFR1 | IC50: 0.2nM |
| FGFR3 | IC50: 1.8nM |
| FGFR2 | IC50: 2.5nM |
| KDR | IC50: 24nM |
| FGFR4 | IC50: 165nM |
| IGFR | IC50: 581nM |
| Axl | IC50: >2μM |
| CDK2 | IC50: >10μM |
| FAK | IC50: >10μM |
| ROCK2 | IC50: >50μM |
| Akt1 | IC50: >100μM |
| ALK1 | IC50: >100μM |
| p38 | IC50: >100μM |
| PI3Kα | IC50: >100μM |
| In vitro (25°C) | DMSO | 79 mg/mL (170.41 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 4% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.57 mL | 107.85 mL | 215.7 mL |
| 0.5 mM | 4.31 mL | 21.57 mL | 43.14 mL |
| 1 mM | 2.16 mL | 10.79 mL | 21.57 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.31 mL |
*The above data is based on the productmolecular weight 463.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11075 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 463.6 |
| Formula | C26H33N5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1035270-39-3 |
| Synonyms | AZD-4547 |
| SMILES | C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC |
产品标签
Product Questions
Product Questions
No Questions
您还可能对下列产品感兴趣
Alofanib (RPT835)
Alofanib (RPT835)是FGFR2的强效选择性变构抑制剂，具有潜在的抗癌活性。
Pazopanib (GW-786034)
Pazopanib (GW-786034)是VEGFR-1，VEGFR-2，VEGFR-3，PDGFR-a/β和c-kit的有效且选择性的多靶点酪氨酸激酶抑制剂，可阻…
Pazopanib HCl (GW786034)
Pazopanib HCl (GW786034)是VEGFR-1，VEGFR-2，VEGFR-3，PDGFR-a/β和c-kit的有效且选择性的多靶点酪氨酸激酶抑制剂，可…
NVP-BGJ398 phosphate
NVP-BGJ398 phosphate是一种新型的选择性泛特异性FGFR抑制剂，对FGFR1，FGFR2和FGFR3的IC50分别为0.9、1.4和1 nM。与FGF…
Debio-1347 (CH5183284)
Debio-1347 (CH5183284)是成纤维细胞生长因子受体亚型1（FGFR-1），2（FGFR-2）和3（FGFR-3）的生物利用抑制剂，具…
Erdafitinib (JNJ-42756493)
Erdafitinib (JNJ-42756493)是一种有效且选择性的口服生物利用型泛成纤维细胞生长因子受体（FGFR）抑制剂，具…
LY 2874455
LY2874455是一种新型有效的FGFR / VEGFR抑制剂。
Keywords:购买 AZD4547 | AZD4547 供应商 | 订购 AZD4547 | AZD4547 价格 | AZD4547 生产商 | 订单 AZD4547 | AZD4547 代理商 | 购买 1035270-39-3| 1035270-39-3 供应商 | 订购 1035270-39-3 | 1035270-39-3 价格 | 1035270-39-3 生产商 | 订单 1035270-39-3 | 1035270-39-3 代理商|buy AZD4547 | AZD4547 Supplier | purchase AZD4547 | AZD4547 cost | AZD4547 manufacturer | order AZD4547 | AZD4547 distributor | buy 1035270-39-3| 1035270-39-3 Supplier | purchase 1035270-39-3 | 1035270-39-3 cost | 1035270-39-3 manufacturer | order 1035270-39-3 | 1035270-39-3 distributor