AZD5582

Name: AZD5582
SKU: A21735
Price: 280 CNY
Rating: 5 (288 reviews)

目录号: A21735

IAPs 拮抗剂

AZD5582 是一种抑制凋亡蛋白抑制剂（IAPs）的拮抗剂，它与 BIR3 结构域的 cIAP1、cIAP2 和 XIAP 结合，其 IC50 分别为 15、21 和 15 nM。

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规格	价格	库存
1mg	¥280.00	现货
5mg	¥630.00	现货
10mg	¥980.00	现货
50mg	¥3,325.00	现货
100mg	¥5,740.00	现货
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Data Sheet

SDS

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生物活性

Discription

AZD5582 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively.

Targets

Cell Research

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Cell Line	Type	Value	Description	References
MDA-MB-231	GI50	< 0.06 nM	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition after 48 hrs by Alamar Blue assay	[PMID: 24320998]
MDA-MB-231	EC50	0.1 nM	Binding affinity to cIAP1 in human MDA-MB-231 cells assessed as induction of protein degradation after 1 hr by ELISA	[PMID: 24320998]

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产品信息

目录号	A21735
分子式	C58H78N8O8
分子量	1015.29
CAS号	1258392-53-8
SMILES	CN[C@@H](C)C(N[C@H](C(N1[C@H](C(N[C@H]2C3=CC=CC=C3C[C@H]2OCC#CC#CCO[C@H]4[C@@H](NC([C@@H]5CCCN5C([C@@H](NC([C@H](C)NC)=O)C6CCCCC6)=O)=O)C(C=CC=C7)=C7C4)=O)CCC1)=O)C8CCCCC8)=O
其他名称	AZD 5582, AZD-5582
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	98 mg/mL (96.52 mM)
	Water	98 mg/mL (96.52 mM)
	* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	9.85 mL	49.25 mL	98.49 mL
0.5 mM	1.97 mL	9.85 mL	19.7 mL
1 mM	0.98 mL	4.92 mL	9.85 mL
5 mM	0.2 mL	0.98 mL	1.97 mL

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