产品详情

生物活性

AZD6482是一种PI3Kβ抑制剂，(IC50 = 0.021M)。

靶点信息

PI3Kβ (Cell-free assay)	PI3Kδ (Cell-free assay)	DNA-PK (Cell-free assay)	PI3Kα (Cell-free assay)	PI3Kγ (Cell-free assay)
10 nM	80 nM	420 nM	870 nM	1090 nM

溶解度 *

In vitro (25°C)	DMSO	74 mg/mL (181.16 mM)
	Water	Insoluble
	Ethanol	9 mg/mL (22.03 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.48 mL	122.4 mL	244.8 mL
0.5 mM	4.9 mL	24.48 mL	48.96 mL
1 mM	2.45 mL	12.24 mL	24.48 mL
5 mM	0.49 mL	2.45 mL	4.9 mL

*The above data is based on the productmolecular weight 408.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10112
作用机制	Inhibitor (抑制剂)
M. Wt	408.5
Formula	C22H24N4O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1173900-33-8
Synonyms	AZD-6482
SMILES	CC1=CN2C(=O)C=C(N=C2C(=C1)[C@@H](C)NC3=CC=CC=C3C(=O)O)N4CCOCC4