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AZD7762是一种有效的ATP竞争性检查点激酶抑制剂，可促进检查点废止并增强DNA靶向疗法。
靶点信息
| Chk1 (Cell-free assay) | Chk2 (Cell-free assay) | |||
| 5 nM | <10 nM |
| In vitro | DMSO | 50 mg/mL (137.96 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.59 mL | 137.97 mL | 275.94 mL |
| 0.5 mM | 5.52 mL | 27.59 mL | 55.19 mL |
| 1 mM | 2.76 mL | 13.8 mL | 27.59 mL |
| 5 mM | 0.55 mL | 2.76 mL | 5.52 mL |
*The above data is based on the productmolecular weight 362.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10113 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 362.4 |
| Formula | C17H19FN4O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 860352-01-8 |
| Synonyms | AZD-7762 |
| SMILES | C1C[C@@H](CNC1)NC(=O)C2=C(C=C(S2)C3=CC(=CC=C3)F)NC(=O)N |
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