Bardoxolone methyl (RTA 402)

Name: Bardoxolone methyl (RTA 402)
SKU: A11323
Price: 175 CNY
Rating: 5 (5 reviews)

目录号: A11323

IκB/IKK 抑制剂

5 篇发表文献

Bardoxolone methyl 是一种口服的首创合成三萜类化合物。它是 Nrf2 通路的诱导剂，可以抑制氧化应激和炎症。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥210.00	现货
25mg	¥350.00	现货
50mg	¥525.00	现货
100mg	¥805.00	现货
200mg	¥1,330.00	现货
500mg	¥3,080.00	现货
*10mM 1mL in DMSO**	¥245.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Bardoxolone methyl (RTA 402)发表的5篇文献

May Barakat, .et al. , Sci Rep, 2024, Oct 24;14(1):25258 PMID: 39448644

Nakamura S, .et al. , Invest Ophthalmol Vis Sci, 2019, 60: 1943-1952 PMID: 31050722

Hisamichi M, .et al. , Hypertens Res, 2018, Jan;41(1):8-17 PMID: 28978980

Takahiko Imai, .et al. , Neurobiol Dis, 2016, May;89:136-46 PMID: 26850917

Takagi T, .et al. , Free Radic Biol Med, 2014, 72:124-33 PMID: 24746614

生物活性

Discription

Bardoxolone methyl is an orally-available first-in-class synthetic triterpenoid. It is an inducer of the Nrf2 pathway, which can suppress oxidative stress and inflammation.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11323
分子式	C32H43NO4
分子量	505.7
CAS号	218600-53-4
SMILES	C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC
其他名称	NSC 713200, CDDO-methyl ester
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	21 mg/mL (41.52 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4%DMSO+30% PEG300+5% Tween+61%ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.77 mL	98.87 mL	197.75 mL
0.5 mM	3.95 mL	19.77 mL	39.55 mL
1 mM	1.98 mL	9.89 mL	19.77 mL
5 mM	0.4 mL	1.98 mL	3.95 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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