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Bardoxolone methyl (RTA 402)

Bardoxolone methyl (RTA 402)

Name: Bardoxolone methyl (RTA 402)
SKU: A11323

目录号: A11323

IκB/IKK 抑制剂

Product Citations (4)

Bardoxolone methyl (RTA 402) Chemical Structure

CAS NO. 218600-53-4

Bardoxolone甲基是口服的一流的合成三萜类化合物。它是Nrf2途径的诱导剂，可以抑制氧化应激和炎症。

库存：现货

规格	价格	数量
25 mg	￥ 420.00
50 mg	￥ 630.00
100 mg	￥ 945.00
200 mg	￥ 1,575.00
10mM * 1mL in DMSO	￥ 420.00

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生物活性

Bardoxolone甲基是口服的一流的合成三萜类化合物。它是Nrf2途径的诱导剂，可以抑制氧化应激和炎症。

靶点信息

IKK (Cell-free assay)

溶解度 *

In vitro (25°C)	DMSO	21 mg/mL (41.52 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4%DMSO+30% PEG300+5% Tween+61%ddH2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.77 mL	98.87 mL	197.75 mL
0.5 mM	3.95 mL	19.77 mL	39.55 mL
1 mM	1.98 mL	9.89 mL	19.77 mL
5 mM	0.4 mL	1.98 mL	3.95 mL

*The above data is based on the productmolecular weight 505.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11323
作用机制	Inhibitor (抑制剂)
M. Wt	505.7
Formula	C32H43NO4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	218600-53-4
Synonyms	NSC 713200, CDDO-methyl ester
SMILES	C[C@@]12CC[C@]3(CCC(C[C@H]3[C@H]1C(=O)C=C4[C@]2(CC[C@@H]5[C@@]4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C)C(=O)OC