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Bay 11-7821是TNF-α刺激的IκBα磷酸化的不可逆抑制剂。
靶点信息
| E2-conjugating enzymes (Cell-free assay) | IκBα?phosphorylation (Tumor cells) | |||
| N/A | 10 μM |
| In vitro (25°C) | DMSO | 39 mg/mL (188.17 mM) | |
| Water | Insoluble | ||
| Ethanol | 10 mg/mL (48.25 mM) | ||
| In vivo | 5% DMSO+corn oil | 7 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 48.25 mL | 241.25 mL | 482.51 mL |
| 0.5 mM | 9.65 mL | 48.25 mL | 96.5 mL |
| 1 mM | 4.83 mL | 24.13 mL | 48.25 mL |
| 5 mM | 0.97 mL | 4.83 mL | 9.65 mL |
*The above data is based on the productmolecular weight 207.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11957 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 207.25 |
| Formula | C10H9NO2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 19542-67-7 |
| Synonyms | Bay-11-7821, Bay 117821, Bay117821,Bay 11-7082, Bay-11-7082, Bay11-7082 |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N |
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