Bedaquiline (TMC-207)

Name: Bedaquiline (TMC-207)
SKU: A12327
Price: 280 CNY
Rating: 5 (18 reviews)

目录号: A12327

18 篇发表文献

TMC207 是一种首创类二芳基喹啉化合物，具有新颖的作用机制——抑制细菌ATP合酶，并对敏感和耐药性结核病（TB）具有强大的活性。

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Grouped product items
规格	价格	库存
5mg	¥280.00	现货
10mg	¥455.00	现货
25mg	¥735.00	现货
50mg	¥1,050.00	现货
100mg	¥1,330.00	现货
250mg	¥2,380.00	现货
500mg	¥3,395.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

Other Forms of Bedaquiline (TMC-207)

Bedaquiline fumarate

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Bedaquiline (TMC-207)发表的18篇文献

Boatema Ofori-Anyinam, .et al. , Nat Commun, 2024, Nov 13;15(1):9792 PMID: 39537610

Khomotso Mmakola, .et al. , Preprints, 2024, Sep 18

Asmita Sapkota, .et al. , Biomed Pharmacother, 2024, Oct:179:117313 PMID: 39167844

Thanh Quang Nguyen, .et al. , Microbiol Spectr, 2023, Jun 15;11(3):e0063123 PMID: 37158736

Rubeshan Perumal, .et al. , Infect Drug Resist, 2023, May 9;16:2849-2859 PMID: 37193296

Christian C Otum, .et al. , Sci Rep, 2023, Jun 6;13(1):9212 PMID: 37280265

Thanh Quang Nguyen, .et al. , Antimicrob Agents Chemother, 2022, Dec 20;66(12):e0044822 PMID: 36321819

Jinsheng Cui, .et al. , Mar Drugs, 2022, Jun 16;20(6):400 PMID: 35736203

Bettina Schulthess, .et al. , Antimicrob Agents Chemother, 2022, May 17;66(5) PMID: 35420492

Puyskens A, .et al. , Cell Host Microbe, 2019, Dec 23. pii: S1931-3128(19)30634-1 PMID: 31901518

Belosludtsev KN, .et al. , Biochim Biophys Acta Biomembr, 2019, Jan;1861(1):288-297 PMID: 29920239

Meikle V, .et al. , Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480

Belosludtsev KN, .et al. , Chem Biol Interact, 2018, Nov 26;299:8-14 PMID: 30496736

Wu X, .et al. , Biochem Biophys Res Commun, 2018, Jan 1;495(1):267-272 PMID: 29107691

Jichan Jang, .et al. , Antimicrob Agents Chemother, 2017, Jul; 61(7): e02637-16 PMID: 28416541

Marco Fiorillo, .et al. , Aging (Albany NY), 2016, Aug; 8(8): 1593-1606 PMID: 27344270

Alvaro A. Ordonez, .et al. , Antimicrob Agents Chemother, 2015, Jan; 59(1): 642-649 PMID: 25403669

Ke Liu, .et al. , Drug Metab Dispos, 2014, May; 42(5): 863-866 PMID: 24513655

生物活性

Discription

TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12327
分子式	C32H31BrN2O2
分子量	555.5
CAS号	843663-66-1
SMILES	CN(C)CC[C@@](C1=CC=CC2=CC=CC=C21)([C@H](C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	11 mg/mL (19.8 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (5.4 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18 mL	90.01 mL	180.02 mL
0.5 mM	3.6 mL	18 mL	36 mL
1 mM	1.8 mL	9 mL	18 mL
5 mM	0.36 mL	1.8 mL	3.6 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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