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Berberine hydrochloride被发现具有对心血管系统的多种有益作用和显着的抗炎活性。 小ber碱可有效降低LPS刺激的巨噬细胞的细胞内超氧化物水平。 小碱对细胞氧化还原的这种恢复是通过其对gp91phox表达的选择性抑制和SOD活性的增强而介导的。
靶点信息
| In vitro (25°C) | DMSO | 35 mg/mL (94.13 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 4% DMSO+30% PEG 300+ddH2O | 2 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.9 mL | 134.48 mL | 268.96 mL |
| 0.5 mM | 5.38 mL | 26.9 mL | 53.79 mL |
| 1 mM | 2.69 mL | 13.45 mL | 26.9 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.38 mL |
*The above data is based on the productmolecular weight 371.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10126 |
|---|---|
| M. Wt | 371.8 |
| Formula | C20H18ClNO4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 633-65-8 |
| SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC5=C(C=C4CC3)OCO5)OC.[Cl-] |
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