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BETd-260 is a potent BET degrader based on PROTAC technology, with as low as 30 pM against BRD4 protein in RS4;11 leukemia cell line.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.52 mL | 62.59 mL | 125.17 mL |
| 0.5 mM | 2.5 mL | 12.52 mL | 25.03 mL |
| 1 mM | 1.25 mL | 6.26 mL | 12.52 mL |
| 5 mM | 0.25 mL | 1.25 mL | 2.5 mL |
*The above data is based on the productmolecular weight 798.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12563 |
|---|---|
| 作用机制 | Degrader (降解剂) |
| M. Wt | 798.89 |
| Formula | C43H46N10O6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2093388-62-4 |
| Synonyms | BETd260, BETd 260, ZBC 260, ZBC-260, ZBC260 |
| SMILES | CCN1N=C(C2CC2)C=C1NC3=NC(C(NCCCCCC4=CC=CC5=C4CN(C6C(NC(CC6)=O)=O)C5=O)=O)=NC7=C3C8=CC(OC)=C(C9=C(C)ON=C9C)C=C8N7 |
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