产品详情

生物活性

BG45是一种HDAC I类抑制剂，对HDAC3具有选择性（IC50 = 289 nM）。它抑制HDAC1，HDAC2和HDAC6的效力大大降低（IC50分别为2、2和> 20μM）。

靶点信息

HDAC3	HDAC1	HDAC2	HDAC6
289 nM	2 μM	2.2 μM	>20 μM

溶解度 *

In vitro	DMSO	40 mg/mL (186.72 mM)
	Water	Insoluble
	Ethanol	Warmed: 2 mg/mL (9.33 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	46.68 mL	233.4 mL	466.81 mL
0.5 mM	9.34 mL	46.68 mL	93.36 mL
1 mM	4.67 mL	23.34 mL	46.68 mL
5 mM	0.93 mL	4.67 mL	9.34 mL

*The above data is based on the productmolecular weight 214.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11361
作用机制	Inhibitor (抑制剂)
M. Wt	214.22
Formula	C11H10N4O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	926259-99-6
Synonyms	BG 45, BG-45
SMILES	NC1=CC=CC=C1/N=C(O)/C2=CN=CC=N2