BI-847325

Name: BI-847325
SKU: A15762
Price: 280 CNY
Rating: 5 (3 reviews)

目录号: A15762

MEK/Aurora 抑制剂

3 篇发表文献

BI-847325 是一种口服生物利用度高的、选择性的双重 MEK/Aurora 激酶抑制剂，其半抑制浓度（IC50）分别为：针对 Xenopus laevis Aurora B 为 3 nM，针对人类 Aurora A 和 Aurora C 为 25 nM 和 15 nM，以及针对人类 MEK1 和 MEK2 为 25 nM 和 4 nM。目前处于临床试验第一阶段。

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Grouped product items
规格	价格	库存
1mg	¥280.00	现货
2mg	¥350.00	现货
5mg	¥665.00	现货
10mg	¥1,190.00	现货
25mg	¥2,450.00	现货
50mg	¥3,675.00	现货
100mg	¥5,320.00	现货
*10mM 1mL in DMSO**	¥700.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用BI-847325发表的3篇文献

Hilda Samimi, .et al. , Cancer Cell Int, 2022, Dec 8;22(1):388 PMID: 36482411

Hilda Samimi, .et al. , Thyroid Res, 2021, Dec 3;14(1):27 PMID: 34861882

Hilda Samimi, .et al. , DARU J Pharm Sci, 2019, 1-7 PMID: 31077090

生物活性

Discription

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.

Targets

Target	Value

产品信息

目录号	A15762
分子式	C29H28N4O2
分子量	464.56
CAS号	1207293-36-4
SMILES	CCNC(C#CC1=CC=C2C(NC(/C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4)=O)=C1)=O
其他名称	BI 847325, BI847325
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 19 mg/mL (40.89 mM)
	Water	Insoluble
	Ethanol	1 mg/mL (2.15 mM)
In vivo	2-hydroxyethyl cellulose, polysorbate 80 with pH adjusted to 2.8 with 1 M HCl	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.53 mL	107.63 mL	215.26 mL
0.5 mM	4.31 mL	21.53 mL	43.05 mL
1 mM	2.15 mL	10.76 mL	21.53 mL
5 mM	0.43 mL	2.15 mL	4.31 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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