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BI6727 (Volasertib)

BI6727 (Volasertib)

Name: BI6727 (Volasertib)
SKU: A10135

目录号: A10135

PLK 抑制剂

Product Citations (1)

BI6727 (Volasertib) Chemical Structure

CAS NO. 755038-65-4

BI6727 (Volasertib)是一种高效且选择性的polo样激酶（PLK）1抑制剂（在一组癌细胞系中，酶IC50 = 0.87 nM，EC50 = 11-37 nM）。

库存：现货

规格	价格	数量
5 mg	￥ 525.00
10 mg	￥ 973.00
50 mg	￥ 3,150.00
100 mg	￥ 5,250.00
10mM * 1mL in DMSO	￥ 1,064.00

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生物活性

BI6727 (Volasertib)是一种高效且选择性的polo样激酶（PLK）1抑制剂（在一组癌细胞系中，酶IC50 = 0.87 nM，EC50 = 11-37 nM）。

靶点信息

PLK1 (Cell-free assay)
0.87 nM

溶解度 *

In vitro (25°C)	DMSO	Warmed: 19 mg/mL (30.7 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+corn oil	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.16 mL	80.8 mL	161.6 mL
0.5 mM	3.23 mL	16.16 mL	32.32 mL
1 mM	1.62 mL	8.08 mL	16.16 mL
5 mM	0.32 mL	1.62 mL	3.23 mL

*The above data is based on the productmolecular weight 618.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10135
作用机制	Inhibitor (抑制剂)
M. Wt	618.8
Formula	C34H50N8O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	755038-65-4
Synonyms	Volasertib, BI-6727
SMILES	CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C