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BIBR 1532是一种选择性端粒酶抑制剂（人端粒酶，人RNA聚合酶I和人RNA聚合酶II + III的IC50值分别为93，> 100000和> 100000 nM）。
靶点信息
| Telomerase (Cell-free assay) | ||||
| 100 nM |
| In vitro (25°C) | DMSO | 58 mg/mL (175.03 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (9.05 mM) | ||
| In vivo | 5% DMSO+corn oil | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.18 mL | 150.88 mL | 301.75 mL |
| 0.5 mM | 6.04 mL | 30.18 mL | 60.35 mL |
| 1 mM | 3.02 mL | 15.09 mL | 30.18 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.04 mL |
*The above data is based on the productmolecular weight 331.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10140 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 331.4 |
| Formula | C21H17NO3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 321674-73-1 |
| Synonyms | BIBR-1532, BIBR1532 |
| SMILES | C/C(=C\C(=O)NC1=CC=CC=C1C(=O)O)/C2=CC3=CC=CC=C3C=C2 |
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