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BIBR 953 (Dabigatran, Pradaxa)

BIBR 953 (Dabigatran, Pradaxa)

Name: BIBR 953 (Dabigatran, Pradaxa)
SKU: A10138

目录号: A10138

Thrombin 抑制剂

Product Citations (1)

BIBR 953 (Dabigatran, Pradaxa) Chemical Structure

CAS NO. 211914-51-1

BIBR 953 (Dabigatran,Pradaxa)是一种高度选择性，可逆且有效的凝血酶抑制剂，可作为前药达比加群酯口服。它在血栓形成的动物模型中显示出抗血栓形成的功效，起效迅速，可预测的药效学反应。

库存：现货

规格	价格	数量
5 mg	￥ 560.00
10 mg	￥ 980.00
50 mg	￥ 3,150.00
100 mg	￥ 5,040.00

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产品仅用于科学研究，不针对患者销售，望谅解.

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生物活性

靶点信息

Thrombin (Cell-free assay)
9.3 nM

溶解度 *

In vitro (25°C)	DMSO	<1 mg/mL
	Water	29 mg/mL (61.5 mM)
	Ethanol	0.01 mg/mL (0.02 mM)
In vivo	10% Trifluoroacetic acid water solution	31 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.21 mL	106.04 mL	212.09 mL
0.5 mM	4.24 mL	21.21 mL	42.42 mL
1 mM	2.12 mL	10.6 mL	21.21 mL
5 mM	0.42 mL	2.12 mL	4.24 mL

*The above data is based on the productmolecular weight 471.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10138
作用机制	Inhibitor (抑制剂)
M. Wt	471.5
Formula	C25H25N7O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	211914-51-1
Synonyms	BIBR-953, BIBR953
SMILES	CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)N